Chuck Bryant and Josh Clark meld their popular podcast called "Stuff You Should Know," which generates more than 5 million monthly downloads, into a same-named, scripted TV series. It follows the two inside and outside the recording booth as they prepare the podcasts, which are woven into deadpan mockumentary-style plots where scientific facts collide with ridiculous fictional adventures. Among the wide array of guests who make cameo appearances in the series are John Hodgman, Sarah Silverman, Neil deGrasse Tyson, Rufus Wainwright and Michio Kaku.